Prof. Brik is the Jordan and Irene Tark Academic Professor at the Schulich Faculty of Chemistry at the Technion – the Israel Institute of Technology. He received his B.Sc. in Chemistry from the Ben-Gurion University (1996), and his M.Sc. (1998) and Ph.D. (2001) from the Technion . After spending three years as a postdoc and two years as a senior research associate at the Scripps Research Institute, Brik returned to the Chemistry Department at his alma mater as an Assistant Professor (2007). He was promoted to Associate Professor in 2011, and to a full Professor in 2012. In 2015 Brik moved to the Schulich Faculty of Chemistry at the Technion, where he leads an interdisciplinary research group in Chemical Biology. His research involves the development of novel approaches to shed light on fundamental questions regarding the role of posttranslational modifications in cellular processes, overcoming the various limitations of enzymatic approaches to obtain these modified proteins.

This has enabled numerous studies in a wide field of research, from investigating the role of ubiquitination and phosphorylation in Parkinson’s disease to epigenetics. Brik has also pioneered the development of chemical tools to study and target deubiquitinates and discover effective macrocyclic peptides that can tightly and specifically bind Lys48-linked ubiquitin chains and attenuate tumor growth in a mouse model. Brik has received several national and international awards, including the Bruno Award, the Israel Chemical Society Prize for Excellence, the Teva Award, the 11th Hirta Award (Japan), and the Tetrahedron Young Investigator Award by Elsevier. 

In 2019 Prof. Brick was elected a member of the Israeli Young Academy and in May 2024 he was elected to the Israeli National Academy of Sciences, the highest body in the science community in Israel.